Linear DNA Does Not Form Chromatin Containing Regularly Spaced Nucleosomes
نویسندگان
چکیده
منابع مشابه
Simian virus 40 chromatin showing nucleosomes in linear bead-like arrangements along extended closed circular DNA.
Viral nucleoprotein complexes were extracted from nuclei of permissive cells (CV-1) infected with simian virus 40 (SV40) and examined by electron microscopy. SV40 nucleoprotein complexes (SV40 chromatin) showed nucleosomes in linear bead-like arrangements along the extended closed circular DNA. The contour length of the SV40 chromatin was only 1.0-1.8 times shorter than that of viral DNA obtain...
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In a eukaryotic cell, genomic DNA does not exist in a free state, but is intricately complexed with chromosomal proteins, particularly histones. The basic chromatin fibre consists of an array of nucleosomes, each packaging around 200 base pairs (bp) of DNA; 146 bp is wound around a core of eight histone molecules (two each of H2A, H2B, H3 and H4), with the remaining DNA forming a linker to the ...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1982
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.2.12.1608